Protein Resins
AdipoGen Jagged-1 hFc h rec
Protein. Signal peptide and extracellular domain of human Jagged-1 HJ1 CD339 aa 1-1067 are fused at the C-terminus to the Fc portion of human IgG1. Source HEK 293 cells. Endotoxin content <0.1EU/µg purified protein LAL test Lonza. Liquid. 0.2µm-filtered solution in PBS. Purity >90% SDS-PAGE. Jagged-1 is a ligand for multiple Notch receptors and involved in the mediation of Notch signaling. It is involved in cell-fate decisions during hematopoiesis. Is involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis in vitro. Defects in Jagged-1 are the cause of Alagille syndrome type 1 ALGS1 and tetralogy of Fallot TOF.
AdipoGen Progranulin rat rec
Protein. Signal peptide and rat progranulin aa 1-602 are fused at the C-terminus to a FLAG -tag. Source HEK 293 cells. Endotoxin content <0.1EU/µg purified protein LAL test Lonza. Lyophilized from 0.2µm-filtered solution in PBS. Purity >95% SDS-PAGE. Progranulin PGRN is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration FTLD. In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer‘s Disease AD and potentially for MCI Mild Cognitive Impairment. Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.
AdipoGen TNF-alpha Soluble h rec
Protein. A FLAG -tag is fused at the N-terminus of human TNF-alpha aa 85-223. Source E. coli. Endotoxin content <0.01EU/µg purified protein LAL test Lonza. Lyophilized. Contains PBS. Binds to human and mouse TNF-R1. Purity >95% SDS-PAGE. Tumor necrosis factor TNF, cachexin or cachectin and formerly known as tumor necrosis factor-alpha is a cytokine involved in systemic inflammation and is a member of a group of cytokines that stimulate the acute phase reaction. The receptor TNF-R1 is activated by both the membrane-bound and soluble trimeric forms of TNF-alpha, whereas the receptor TNF-R2 only responds to the membrane-bound form of TNF-alpha MultimericTNF-alpha Prod. No. AG-40B-0019. Since the MultimericTNF-alpha mimics the membrane-bound form forms oligomers higher than trimer, it is the only TNF-alpha protein that can activate the TNF-R2. For TNF-R1 activation, either "normal" TNF-alpha or MultimericTNF-alpha can be used.
American Research Products Inc Mouse High mobility group prot
Mouse High mobility group protein B1 HMGB-1 ELISA Kit from CUSABIO Detection Range 15 6 pg/mL-1000 pg/mL Sensitivity 3 9 pg/mL Sample serum plasma tissue homogenates cell lysates Method Sandwich
American Research Products Inc Human protein arginine deimina
Human protein-arginine deiminase type-4 (PADI4) ELISA kit from CUSABIO Detection Range 0 156 ng/mL-10 ng/mL Sensitivity 0 039 ng/mL Sample serum urine cell culture supernates Method Sandwich
Biolegend Direct-BlotTM HRP anti-HMGB1
Direct-Blot™ HRP anti-HMGB1 [3E8]; Isotype: Mouse IgG2b, κ; Reactivity: Human, Mouse, Rat; Apps: WB; Size: 100 μL
AdipoGen CD137 mouseFc h rec
Protein. The extracellular domain of mouse CD137 aa 1-185 is fused at the C-terminus to the Fc portion of human IgG1. Source HEK 293 cells. Endotoxin content <0.1EU/µg purified protein LAL test Lonza. Liquid. 0.2µm filtered solution in PBS. Purity >95% SDS-PAGE. CD137 4-1BB is a member of the tumor necrosis factor TNF receptor family. CD137 is expressed by activated T cells, dendritic cells, NK cells, granulocytes and cells of blood vessel walls at sites of inflammation. CD137 has costimulatory activity for activated T cells. Crosslinking of CD137 enhances T cell proliferation, IL-2 secretion survival and cytolytic activity. CD137 was shown to enhance immune activity to eliminate tumors in mice.
American Research Products Inc Fish Heat Shock Protein 70 HS
Fish Heat Shock Protein 70 (HSP-70) ELISA Kit from CUSABIO Detection Range 18 75 pg/mL-300 pg/mL Sensitivity 18 75 pg/mL Sample serum plasma tissue homogenates Method Competitive